If you say that something happens or should happen irrespective of a particular thing, you mean that it is not affected or should not be affected by that thing.
例句
...their commitment to a society based on equality for all citizens irrespective of ethnic origin...他们承诺建立一个不分种族出身、全民平等的社会This service should be available to everybody, irrespective of whether they can afford it.这项服务应该面向所有人,不管他们是否负担得起。
英汉词典释义
adj.
不顾的;不问...的;与...无关的
He is going to buy it irrespective of what you say.不管你说什么, 他是买定了。
英英词典释义
Adverb
1. in spite of everything; without regard to drawbacks;