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（生理或智力上的）残障，残疾
A handicap is a physical or mental disability.
例句
He lost his leg when he was ten, but learnt to overcome his handicap.
他10岁时失去了一条腿，但他学会了克服自己的残疾。
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不利条件;障碍
A handicap is an event or situation that places you at a disadvantage and makes it harder for you to do something.
例句
She was away from school for 15 weeks, a handicap she could have done without...
她有15周没上学，这给她带来了本不该有的障碍。
Being a foreigner was not a handicap.
身为外国人并不是一个障碍。
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VERB
妨碍;使不利
If an event or a situation handicaps someone or something, it places them at a disadvantage.
例句
Greater levels of stress may seriously handicap some students...
压力的加重可能会给一些学生带来严重的负面影响。
The industrial injuries scheme takes into account the actual disability and whether it handicaps a person in working.
工伤赔偿方案要考虑实际残疾情况以及残疾是否会影响其工作能力。
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（高尔夫运动中的）给弱者增加的杆数，差点
In golf, a handicap is an advantage given to someone who is not a good player, in order to make the players more equal. As you improve, your handicap gets lower.
例句
I see your handicap is down from 16 to 12.
我发现你的差点已从16杆降到了12杆。
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（赛马比赛的）让步赛
In horse racing, a handicap is a race in which some competitors are given a disadvantage of extra weight in an attempt to give everyone an equal chance of winning.