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(狮子、狐狸等野生动物的)兽穴，兽窝
A den is the home of certain types of wild animals such as lions or foxes.
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(家里用来学习、工作或从事业余爱好的)书房，私室
Your den is a quiet room in your house where you can go to study, work, or carry on a hobby without being disturbed.
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(通常指为了从事非法活动的)秘密聚集处，窝点，巢穴
A den is a secret place where people meet, usually for a dishonest purpose.
例句
I could provide you with the addresses of at least three illegal drinking dens.
我可以为你提供至少 3 处非法饮酒窝点的地址。
...the crack dens of urban America.
美国城市中的可卡因毒窟
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(某一不良行为或非法活动的猖獗)场所，渊薮
If you describe a place as a den of a particular type of bad or illegal behaviour, you mean that a lot of that type of behaviour goes on there.
例句
...the one-bedroomed flat that was to become his den of savage debauchery.
即将成为他野蛮放荡之所的一居室公寓
...a den of greed.
贪欲横行之地